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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION
FOR ESTIMATION OF GABAPENTIN IN HUMAN PLASMA
AND PHARMACEUTICAL DOSAGE FORMS
A
Thesis Submitted to
GANPAT UNIVERSITY, KHERVA
In Partial Fulfillment of the requirement for the degree of
MASTER OF PHARMACY
IN
THE FACULTY OF PHARMACY
(QUALITY ASSURANCE)
APRIL-2009
Guided By: Submitted By:
Dr. S. A. Patel DUSHYANT PATEL
M. Pharm., Ph. D. B. Pharm.
S. K. PATEL COLLEGE OF PHARMACEUTICAL EDUCATION AND RESEARCH
GANPAT UNIVERSITY, KHERVA - 382711
DIST. – MEHSANA, GUJARAT, INDIA.
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Inhaltsverzeichnis

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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF GABAPENTIN IN HUMAN PLASMA AND PHARMACEUTICAL DOSAGE FORMS A Thesis Submitted to GANP

Seite 2 - CERTIFICATE

Dushyant Patel List of Figures S.K.P.C.P.E.R., Kherva

Seite 3 - DECLARATION

Dushyant Patel List of Abbreviations S.K.P.C.P.E.R., Kherva

Seite 4 - ACKNOWLEDGMENT

Dushyant Patel List of Abbreviations S.K.P.C.P.E.R., Kherva

Seite 5

Dushyant Patel Introduction S.K.P.C.P.E.R., Kherva

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Dushyant Patel Introduction S.K.P.C.P.E.R., Kherva

Seite 7 - SR NO. TITLE

Dushyant Patel Introduction S.K.P.C.P.E.R., Kherva

Seite 8 - List of Tables

Dushyant Patel Introduction S.K.P.C.P.E.R., Kherva

Seite 9

Dushyant Patel Introduction S.K.P.C.P.E.R., Kherva

Seite 10 - List of Figures

Dushyant Patel Introduction S.K.P.C.P.E.R., Kherva

Seite 11

Dushyant Patel Introduction S.K.P.C.P.E.R., Kherva

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This is to certify that the research work embodied in this thesi

Seite 13 - CHAPTER 1: INTRODUCTION

Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

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Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

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Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

Seite 16 - 1.2 DRUG PROFILE

Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

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Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

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Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

Seite 19 - 1.3 REFERENCES:

Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

Seite 20 - 2.1 REVIEW OF LITERATURE:

Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

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Dushyant Patel Review of Literature S.K.P.C.P.E.R., Kherva

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Dushyant Patel Aim of The Present Work S.K.P.C.P.E.R., Kherva

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I hereby declare that this thesis entitled “ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF GABAPENTIN IN HUMAN PLASMA AND PHAR

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 25

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 26 - 2.2 REFERENCES:

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 27 -  J Pharm Biomed Anal

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 29 - 3.1 AIM OF THE PRESENT WORK:

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 30 - IN HUMAN PLASMA

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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` A single flower cannot make a garland or a single star can not make the beautiful shiny sky at the night, same way a research work can never b

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 43 - 4.2 EXPERIMENTAL WORK:

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 44

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 45

I owe a special word of thanks to Mr. Jignesh Bhatt, Dr. Deepak Jain, Dr. Tushar Mehta and Mr. Mohan Kundlik for their profound guidance and shari

Seite 46

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Their firm and kind hearted personality has affected me to be steadfast and never bend to difficulty. They always let me know that they are proud of

Seite 57

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 63 - 4.3 RESULTS AND DISCUSSION:

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 67

Dushyant Patel Index S.K.P.C.P.E.R., Kherva

Seite 68

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 69

Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel LC-MS/MS Method S.K.P.C.P.E.R., Kherva

Seite 78 - 4.4 REFERENCES:

Dushyant Patel List of Tables S.K.P.C.P.E.R., Kherva

Seite 79

Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

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Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

Seite 86 - 5.3 RESULTS AND DISCUSSION:

Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

Seite 87 - Absorbance

Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

Seite 88

Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

Seite 89

Dushyant Patel List of Tables S.K.P.C.P.E.R., Kherva

Seite 90 - 5.4 REFERENCES:

Dushyant Patel Extractive Spectrophotometric Method S.K.P.C.P.E.R., Kherva

Seite 91 - 6.2 CONCLUSION:

Dushyant Patel Summary and Conclusion S.K.P.C.P.E.R., Kherva

Seite 92

Dushyant Patel Summary and Conclusion S.K.P.C.P.E.R., Kherva

Seite 93 - Pharm Sci

Dushyant Patel Presentations and publications S.K.P.C.P.E.R., Kherva

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