Samsung RT34M Bedienungsanleitung PDF herunterladen (Seite 16)

Dushyant Patel Introduction

S.K.P.C.P.E.R., Kherva 4 M .Pharm. Thesis

¾ Surgery

1.2 DRUG PROFILE

15-17

¾ Drug name: Gabapentin

¾ Proprietary name:

o Neurontin , Aclonium

¾ Category: Antiepileptic drug

¾ Iupac name:

o 2-[1-(aminomethyl)cyclohexyl]acetic acid

¾ Structure:

1.2.1 PHYSICOCHEMICAL PROPERTIES:

¾ Molecular Formula: C

¾ Molecular Weight: 171.24 gm/mol

¾ Melting Point: 162-166° C

¾ pKa: 3.68, 10.70

¾ Isoelectric Point: 7.14

¾ Solubility:

o Ethanol : 1 in 90

o Water : 1 in 10

¾ Partition Coefficient:

o Octanol/Water: 0.075

¾ Log P: -1.10

¾ It is white to off-white crystalline solid

1.2.2 PHARMACOKINETICS PROPERTIES:

¾ Oral Absorption : ~60%(Dose Dependent)

¾ Presystemic Metabolism : NIL

¾ Plasma Half Life : 5-7 hrs

¾ Volume Of Distribution : 0.6 to 0.8 l/kg

¾ Plasma Protein Binding : < 3%

¾ Dose(mg) : 300 mg 600 mg 900 mg

¾ Cmax(mg/l) : 2.7 mg/l 3.29 mg/l 4.02 mg/l

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